Independent contribution of temporal β-amyloid deposition to memory decline in the pre-dementia phase of Alzheimer's disease
Identifieur interne : 006A01 ( Main/Exploration ); précédent : 006A00; suivant : 006A02Independent contribution of temporal β-amyloid deposition to memory decline in the pre-dementia phase of Alzheimer's disease
Auteurs : Gaël Chetelat [Australie, France] ; Victor L. Villemagne [Australie] ; Kerryn E. Pike [Australie] ; Kathryn A. Ellis [Australie] ; Pierrick Bourgeat [Australie] ; Gareth Jones [Australie] ; Graeme J. O'Keefe [Australie] ; Olivier Salvado [Australie] ; Cassandra Szoeke [Australie] ; Ralph N. Martins [Australie] ; David Ames [Australie] ; Colin L. Masters [Australie] ; Christopher C. Rowe [Australie]Source :
- Brain [ 0006-8950 ] ; 2011.
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- Pascal (Inist)
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Abstract
The relationship between β-amyloid deposition and memory deficits in early Alzheimer's disease is unresolved, as past studies show conflicting findings. The present study aims to determine the relative contribution of regional β-amyloid deposition, hippocampal atrophy and white matter integrity to episodic memory deficits in non-demented older individuals harbouring one of the characteristic hallmarks of Alzheimer's disease, i.e. with β-amyloid pathology. Understanding these relationships is critical for effective therapeutic development. Brain magnetic resonance imaging and [11C]Pittsburgh Compound B-positron emission tomography scans were obtained in 136 non-demented individuals aged over 60 years, including 93 healthy elderly and 43 patients with mild cognitive impairment. Voxel-based correlations were computed between a memory composite score and grey matter volume, white matter volume and β-amyloid deposition imaging datasets. Hierarchical linear regression analyses were then performed using values extracted in regions of most significant correlations to determine the relative contribution of each modality to memory deficits. All analyses were conducted pooling all groups together as well as within separate subgroups of cognitively normal elderly, patients with mild cognitive impairment and individuals with high versus low neocortical β-amyloid. Brain areas of highest correlation with episodic memory deficits were the hippocampi for grey matter volume, the perforant path for white matter volume and the temporal neocortex for β-amyloid deposition. When considering these three variables together, only hippocampal volume and temporal β-amyloid deposition provided independent contributions to memory deficits. In contrast to global β-amyloid deposition, temporal β-amyloid deposition was still related to memory independently from hippocampal atrophy within subgroups of cognitively normal elderly, patients with mild cognitive impairment or cases with high neocortical β-amyloid. In the pre-dementia stage of Alzheimer's disease, subtle episodic memory impairment is related to β-amyloid deposition, especially in the temporal neocortex, and independently from hippocampal atrophy, suggesting that both factors should be independently targeted in therapeutic trials aimed at reducing cognitive decline.
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Ellis</name><affiliation wicri:level="4"><inist:fA14 i1="05"><s1>Department of Psychiatry, Academic Unit for Psychiatry of Old Age, The University of Melbourne, St Vincent's Aged Psychiatry Service, St George's Hospital</s1><s2>VIC 3101</s2><s3>AUS</s3><sZ>4 aut.</sZ></inist:fA14><country>Australie</country><wicri:noRegion>VIC 3101</wicri:noRegion><orgName type="university">Université de Melbourne</orgName><placeName><settlement type="city">Melbourne</settlement><region type="état">Victoria (État)</region></placeName></affiliation></author><author><name sortKey="Bourgeat, Pierrick" sort="Bourgeat, Pierrick" uniqKey="Bourgeat P" first="Pierrick" last="Bourgeat">Pierrick Bourgeat</name><affiliation wicri:level="1"><inist:fA14 i1="06"><s1>CSIRO Preventative Health National Research Flagship ICTC, The Australian e-Health Research Centre, BioMedIA, Royal Brisbane and Women's Hospital, Herston</s1><s2>QLD 4006</s2><s3>AUS</s3><sZ>5 aut.</sZ><sZ>8 aut.</sZ></inist:fA14><country>Australie</country><wicri:noRegion>QLD 4006</wicri:noRegion></affiliation></author><author><name sortKey="Jones, Gareth" sort="Jones, Gareth" uniqKey="Jones G" first="Gareth" last="Jones">Gareth Jones</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Department of Nuclear Medicine and Centre for PET, Austin Health</s1><s2>VIC 3084</s2><s3>AUS</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>6 aut.</sZ><sZ>7 aut.</sZ><sZ>13 aut.</sZ></inist:fA14><country>Australie</country><wicri:noRegion>VIC 3084</wicri:noRegion></affiliation></author><author><name sortKey="O Keefe, Graeme J" sort="O Keefe, Graeme J" uniqKey="O Keefe G" first="Graeme J." last="O'Keefe">Graeme J. O'Keefe</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Department of Nuclear Medicine and Centre for PET, Austin Health</s1><s2>VIC 3084</s2><s3>AUS</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>6 aut.</sZ><sZ>7 aut.</sZ><sZ>13 aut.</sZ></inist:fA14><country>Australie</country><wicri:noRegion>VIC 3084</wicri:noRegion></affiliation></author><author><name sortKey="Salvado, Olivier" sort="Salvado, Olivier" uniqKey="Salvado O" first="Olivier" last="Salvado">Olivier Salvado</name><affiliation wicri:level="1"><inist:fA14 i1="06"><s1>CSIRO Preventative Health National Research Flagship ICTC, The Australian e-Health Research Centre, BioMedIA, Royal Brisbane and Women's Hospital, Herston</s1><s2>QLD 4006</s2><s3>AUS</s3><sZ>5 aut.</sZ><sZ>8 aut.</sZ></inist:fA14><country>Australie</country><wicri:noRegion>QLD 4006</wicri:noRegion></affiliation></author><author><name sortKey="Szoeke, Cassandra" sort="Szoeke, Cassandra" uniqKey="Szoeke C" first="Cassandra" last="Szoeke">Cassandra Szoeke</name><affiliation wicri:level="1"><inist:fA14 i1="07"><s1>CSIRO Neurodegenerative Disease, Mental Disorders and Brain Health, Preventative Health Flagship, CSIRO Molecular and Health Technologies, Parkville</s1><s2>VIC 3052</s2><s3>AUS</s3><sZ>9 aut.</sZ></inist:fA14><country>Australie</country><wicri:noRegion>VIC 3052</wicri:noRegion></affiliation></author><author><name sortKey="Martins, Ralph N" sort="Martins, Ralph N" uniqKey="Martins R" first="Ralph N." last="Martins">Ralph N. Martins</name><affiliation wicri:level="1"><inist:fA14 i1="08"><s1>Centre of Excellence for Alzheimer's disease Research and Care, School of Exercise Biomedical and Health Sciences, Edith Cowan University, Joondalup</s1><s2>WA 6027</s2><s3>AUS</s3><sZ>10 aut.</sZ></inist:fA14><country>Australie</country><wicri:noRegion>WA 6027</wicri:noRegion></affiliation></author><author><name sortKey="Ames, David" sort="Ames, David" uniqKey="Ames D" first="David" last="Ames">David Ames</name><affiliation wicri:level="3"><inist:fA14 i1="09"><s1>National Ageing Research Institute, Melbourne</s1><s2>VIC 3052</s2><s3>AUS</s3><sZ>11 aut.</sZ></inist:fA14><country>Australie</country><placeName><settlement type="city">Melbourne</settlement><region type="état">Victoria (État)</region></placeName></affiliation></author><author><name sortKey="Masters, Colin L" sort="Masters, Colin L" uniqKey="Masters C" first="Colin L." last="Masters">Colin L. Masters</name><affiliation wicri:level="4"><inist:fA14 i1="03"><s1>The Mental Health Research Institute, The University of Melbourne</s1><s2>VIC 3052</s2><s3>AUS</s3><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>12 aut.</sZ></inist:fA14><country>Australie</country><placeName><settlement type="city">Melbourne</settlement><region type="état">Victoria (État)</region></placeName><orgName type="university">Université de Melbourne</orgName></affiliation></author><author><name sortKey="Rowe, Christopher C" sort="Rowe, Christopher C" uniqKey="Rowe C" first="Christopher C." last="Rowe">Christopher C. Rowe</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Department of Nuclear Medicine and Centre for PET, Austin Health</s1><s2>VIC 3084</s2><s3>AUS</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>6 aut.</sZ><sZ>7 aut.</sZ><sZ>13 aut.</sZ></inist:fA14><country>Australie</country><wicri:noRegion>VIC 3084</wicri:noRegion></affiliation><affiliation wicri:level="4"><inist:fA14 i1="04"><s1>Department of Medicine, Austin Health, The University of Melbourne</s1><s2>VIC 3052</s2><s3>AUS</s3><sZ>2 aut.</sZ><sZ>13 aut.</sZ></inist:fA14><country>Australie</country><placeName><settlement type="city">Melbourne</settlement><region type="état">Victoria (État)</region></placeName><orgName type="university">Université de Melbourne</orgName></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">INIST</idno><idno type="inist">11-0151164</idno><date when="2011">2011</date><idno type="stanalyst">PASCAL 11-0151164 INIST</idno><idno type="RBID">Pascal:11-0151164</idno><idno type="wicri:Area/PascalFrancis/Corpus">001F26</idno><idno type="wicri:Area/PascalFrancis/Curation">004010</idno><idno type="wicri:Area/PascalFrancis/Checkpoint">001984</idno><idno type="wicri:explorRef" wicri:stream="PascalFrancis" wicri:step="Checkpoint">001984</idno><idno type="wicri:doubleKey">0006-8950:2011:Chetelat G:independent:contribution:of</idno><idno type="wicri:Area/Main/Merge">006E35</idno><idno type="wicri:Area/Main/Curation">006A01</idno><idno type="wicri:Area/Main/Exploration">006A01</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a">Independent contribution of temporal β-amyloid deposition to memory decline in the pre-dementia phase of Alzheimer's disease</title><author><name sortKey="Chetelat, Gael" sort="Chetelat, Gael" uniqKey="Chetelat G" first="Gaël" last="Chetelat">Gaël Chetelat</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Department of Nuclear Medicine and Centre for PET, Austin Health</s1><s2>VIC 3084</s2><s3>AUS</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>6 aut.</sZ><sZ>7 aut.</sZ><sZ>13 aut.</sZ></inist:fA14><country>Australie</country><wicri:noRegion>VIC 3084</wicri:noRegion></affiliation><affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Inserm-EPHE-Université de Caen/Basse-Normandie, Unite U923, GIP Cyceron, CHU Cote de Nacre</s1><s2>14074 Caen</s2><s3>FRA</s3><sZ>1 aut.</sZ></inist:fA14><country>France</country><wicri:noRegion>14074 Caen</wicri:noRegion><wicri:noRegion>CHU Cote de Nacre</wicri:noRegion><wicri:noRegion>14074 Caen</wicri:noRegion></affiliation></author><author><name sortKey="Villemagne, Victor L" sort="Villemagne, Victor L" uniqKey="Villemagne V" first="Victor L." last="Villemagne">Victor L. Villemagne</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Department of Nuclear Medicine and Centre for PET, Austin Health</s1><s2>VIC 3084</s2><s3>AUS</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>6 aut.</sZ><sZ>7 aut.</sZ><sZ>13 aut.</sZ></inist:fA14><country>Australie</country><wicri:noRegion>VIC 3084</wicri:noRegion></affiliation><affiliation wicri:level="4"><inist:fA14 i1="03"><s1>The Mental Health Research Institute, The University of Melbourne</s1><s2>VIC 3052</s2><s3>AUS</s3><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>12 aut.</sZ></inist:fA14><country>Australie</country><placeName><settlement type="city">Melbourne</settlement><region type="état">Victoria (État)</region></placeName><orgName type="university">Université de Melbourne</orgName></affiliation><affiliation wicri:level="4"><inist:fA14 i1="04"><s1>Department of Medicine, Austin Health, The University of Melbourne</s1><s2>VIC 3052</s2><s3>AUS</s3><sZ>2 aut.</sZ><sZ>13 aut.</sZ></inist:fA14><country>Australie</country><placeName><settlement type="city">Melbourne</settlement><region type="état">Victoria (État)</region></placeName><orgName type="university">Université de Melbourne</orgName></affiliation></author><author><name sortKey="Pike, Kerryn E" sort="Pike, Kerryn E" uniqKey="Pike K" first="Kerryn E." last="Pike">Kerryn E. Pike</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Department of Nuclear Medicine and Centre for PET, Austin Health</s1><s2>VIC 3084</s2><s3>AUS</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>6 aut.</sZ><sZ>7 aut.</sZ><sZ>13 aut.</sZ></inist:fA14><country>Australie</country><wicri:noRegion>VIC 3084</wicri:noRegion></affiliation><affiliation wicri:level="4"><inist:fA14 i1="03"><s1>The Mental Health Research Institute, The University of Melbourne</s1><s2>VIC 3052</s2><s3>AUS</s3><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>12 aut.</sZ></inist:fA14><country>Australie</country><placeName><settlement type="city">Melbourne</settlement><region type="état">Victoria (État)</region></placeName><orgName type="university">Université de Melbourne</orgName></affiliation></author><author><name sortKey="Ellis, Kathryn A" sort="Ellis, Kathryn A" uniqKey="Ellis K" first="Kathryn A." last="Ellis">Kathryn A. Ellis</name><affiliation wicri:level="4"><inist:fA14 i1="05"><s1>Department of Psychiatry, Academic Unit for Psychiatry of Old Age, The University of Melbourne, St Vincent's Aged Psychiatry Service, St George's Hospital</s1><s2>VIC 3101</s2><s3>AUS</s3><sZ>4 aut.</sZ></inist:fA14><country>Australie</country><wicri:noRegion>VIC 3101</wicri:noRegion><orgName type="university">Université de Melbourne</orgName><placeName><settlement type="city">Melbourne</settlement><region type="état">Victoria (État)</region></placeName></affiliation></author><author><name sortKey="Bourgeat, Pierrick" sort="Bourgeat, Pierrick" uniqKey="Bourgeat P" first="Pierrick" last="Bourgeat">Pierrick Bourgeat</name><affiliation wicri:level="1"><inist:fA14 i1="06"><s1>CSIRO Preventative Health National Research Flagship ICTC, The Australian e-Health Research Centre, BioMedIA, Royal Brisbane and Women's Hospital, Herston</s1><s2>QLD 4006</s2><s3>AUS</s3><sZ>5 aut.</sZ><sZ>8 aut.</sZ></inist:fA14><country>Australie</country><wicri:noRegion>QLD 4006</wicri:noRegion></affiliation></author><author><name sortKey="Jones, Gareth" sort="Jones, Gareth" uniqKey="Jones G" first="Gareth" last="Jones">Gareth Jones</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Department of Nuclear Medicine and Centre for PET, Austin Health</s1><s2>VIC 3084</s2><s3>AUS</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>6 aut.</sZ><sZ>7 aut.</sZ><sZ>13 aut.</sZ></inist:fA14><country>Australie</country><wicri:noRegion>VIC 3084</wicri:noRegion></affiliation></author><author><name sortKey="O Keefe, Graeme J" sort="O Keefe, Graeme J" uniqKey="O Keefe G" first="Graeme J." last="O'Keefe">Graeme J. O'Keefe</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Department of Nuclear Medicine and Centre for PET, Austin Health</s1><s2>VIC 3084</s2><s3>AUS</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>6 aut.</sZ><sZ>7 aut.</sZ><sZ>13 aut.</sZ></inist:fA14><country>Australie</country><wicri:noRegion>VIC 3084</wicri:noRegion></affiliation></author><author><name sortKey="Salvado, Olivier" sort="Salvado, Olivier" uniqKey="Salvado O" first="Olivier" last="Salvado">Olivier Salvado</name><affiliation wicri:level="1"><inist:fA14 i1="06"><s1>CSIRO Preventative Health National Research Flagship ICTC, The Australian e-Health Research Centre, BioMedIA, Royal Brisbane and Women's Hospital, Herston</s1><s2>QLD 4006</s2><s3>AUS</s3><sZ>5 aut.</sZ><sZ>8 aut.</sZ></inist:fA14><country>Australie</country><wicri:noRegion>QLD 4006</wicri:noRegion></affiliation></author><author><name sortKey="Szoeke, Cassandra" sort="Szoeke, Cassandra" uniqKey="Szoeke C" first="Cassandra" last="Szoeke">Cassandra Szoeke</name><affiliation wicri:level="1"><inist:fA14 i1="07"><s1>CSIRO Neurodegenerative Disease, Mental Disorders and Brain Health, Preventative Health Flagship, CSIRO Molecular and Health Technologies, Parkville</s1><s2>VIC 3052</s2><s3>AUS</s3><sZ>9 aut.</sZ></inist:fA14><country>Australie</country><wicri:noRegion>VIC 3052</wicri:noRegion></affiliation></author><author><name sortKey="Martins, Ralph N" sort="Martins, Ralph N" uniqKey="Martins R" first="Ralph N." last="Martins">Ralph N. Martins</name><affiliation wicri:level="1"><inist:fA14 i1="08"><s1>Centre of Excellence for Alzheimer's disease Research and Care, School of Exercise Biomedical and Health Sciences, Edith Cowan University, Joondalup</s1><s2>WA 6027</s2><s3>AUS</s3><sZ>10 aut.</sZ></inist:fA14><country>Australie</country><wicri:noRegion>WA 6027</wicri:noRegion></affiliation></author><author><name sortKey="Ames, David" sort="Ames, David" uniqKey="Ames D" first="David" last="Ames">David Ames</name><affiliation wicri:level="3"><inist:fA14 i1="09"><s1>National Ageing Research Institute, Melbourne</s1><s2>VIC 3052</s2><s3>AUS</s3><sZ>11 aut.</sZ></inist:fA14><country>Australie</country><placeName><settlement type="city">Melbourne</settlement><region type="état">Victoria (État)</region></placeName></affiliation></author><author><name sortKey="Masters, Colin L" sort="Masters, Colin L" uniqKey="Masters C" first="Colin L." last="Masters">Colin L. Masters</name><affiliation wicri:level="4"><inist:fA14 i1="03"><s1>The Mental Health Research Institute, The University of Melbourne</s1><s2>VIC 3052</s2><s3>AUS</s3><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>12 aut.</sZ></inist:fA14><country>Australie</country><placeName><settlement type="city">Melbourne</settlement><region type="état">Victoria (État)</region></placeName><orgName type="university">Université de Melbourne</orgName></affiliation></author><author><name sortKey="Rowe, Christopher C" sort="Rowe, Christopher C" uniqKey="Rowe C" first="Christopher C." last="Rowe">Christopher C. Rowe</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Department of Nuclear Medicine and Centre for PET, Austin Health</s1><s2>VIC 3084</s2><s3>AUS</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>6 aut.</sZ><sZ>7 aut.</sZ><sZ>13 aut.</sZ></inist:fA14><country>Australie</country><wicri:noRegion>VIC 3084</wicri:noRegion></affiliation><affiliation wicri:level="4"><inist:fA14 i1="04"><s1>Department of Medicine, Austin Health, The University of Melbourne</s1><s2>VIC 3052</s2><s3>AUS</s3><sZ>2 aut.</sZ><sZ>13 aut.</sZ></inist:fA14><country>Australie</country><placeName><settlement type="city">Melbourne</settlement><region type="état">Victoria (État)</region></placeName><orgName type="university">Université de Melbourne</orgName></affiliation></author></analytic><series><title level="j" type="main">Brain</title><title level="j" type="abbreviated">Brain</title><idno type="ISSN">0006-8950</idno><imprint><date when="2011">2011</date></imprint></series></biblStruct></sourceDesc><seriesStmt><title level="j" type="main">Brain</title><title level="j" type="abbreviated">Brain</title><idno type="ISSN">0006-8950</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Alzheimer disease</term><term>Amyloid</term><term>Atrophy</term><term>Emission tomography</term><term>Episodic memory</term><term>Hippocampus</term><term>Nervous system diseases</term><term>Positron emission tomography</term></keywords><keywords scheme="Pascal" xml:lang="fr"><term>Démence d'Alzheimer</term><term>Atrophie</term><term>Pathologie du système nerveux</term><term>Amyloïde</term><term>Mémoire épisodique</term><term>Tomoscintigraphie</term><term>Tomographie par émission de positons</term><term>Hippocampe</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">The relationship between β-amyloid deposition and memory deficits in early Alzheimer's disease is unresolved, as past studies show conflicting findings. The present study aims to determine the relative contribution of regional β-amyloid deposition, hippocampal atrophy and white matter integrity to episodic memory deficits in non-demented older individuals harbouring one of the characteristic hallmarks of Alzheimer's disease, i.e. with β-amyloid pathology. Understanding these relationships is critical for effective therapeutic development. Brain magnetic resonance imaging and [<sup>11</sup>C]Pittsburgh Compound B-positron emission tomography scans were obtained in 136 non-demented individuals aged over 60 years, including 93 healthy elderly and 43 patients with mild cognitive impairment. Voxel-based correlations were computed between a memory composite score and grey matter volume, white matter volume and β-amyloid deposition imaging datasets. Hierarchical linear regression analyses were then performed using values extracted in regions of most significant correlations to determine the relative contribution of each modality to memory deficits. All analyses were conducted pooling all groups together as well as within separate subgroups of cognitively normal elderly, patients with mild cognitive impairment and individuals with high versus low neocortical β-amyloid. Brain areas of highest correlation with episodic memory deficits were the hippocampi for grey matter volume, the perforant path for white matter volume and the temporal neocortex for β-amyloid deposition. When considering these three variables together, only hippocampal volume and temporal β-amyloid deposition provided independent contributions to memory deficits. In contrast to global β-amyloid deposition, temporal β-amyloid deposition was still related to memory independently from hippocampal atrophy within subgroups of cognitively normal elderly, patients with mild cognitive impairment or cases with high neocortical β-amyloid. In the pre-dementia stage of Alzheimer's disease, subtle episodic memory impairment is related to β-amyloid deposition, especially in the temporal neocortex, and independently from hippocampal atrophy, suggesting that both factors should be independently targeted in therapeutic trials aimed at reducing cognitive decline.</div></front></TEI><affiliations><list><country><li>Australie</li><li>France</li></country><region><li>Victoria (État)</li></region><settlement><li>Melbourne</li></settlement><orgName><li>Université de Melbourne</li></orgName></list><tree><country name="Australie"><noRegion><name sortKey="Chetelat, Gael" sort="Chetelat, Gael" uniqKey="Chetelat G" first="Gaël" last="Chetelat">Gaël Chetelat</name></noRegion><name sortKey="Ames, David" sort="Ames, David" uniqKey="Ames D" first="David" last="Ames">David Ames</name><name sortKey="Bourgeat, Pierrick" sort="Bourgeat, Pierrick" uniqKey="Bourgeat P" first="Pierrick" last="Bourgeat">Pierrick Bourgeat</name><name sortKey="Ellis, Kathryn A" sort="Ellis, Kathryn A" uniqKey="Ellis K" first="Kathryn A." last="Ellis">Kathryn A. Ellis</name><name sortKey="Jones, Gareth" sort="Jones, Gareth" uniqKey="Jones G" first="Gareth" last="Jones">Gareth Jones</name><name sortKey="Martins, Ralph N" sort="Martins, Ralph N" uniqKey="Martins R" first="Ralph N." last="Martins">Ralph N. Martins</name><name sortKey="Masters, Colin L" sort="Masters, Colin L" uniqKey="Masters C" first="Colin L." last="Masters">Colin L. Masters</name><name sortKey="O Keefe, Graeme J" sort="O Keefe, Graeme J" uniqKey="O Keefe G" first="Graeme J." last="O'Keefe">Graeme J. O'Keefe</name><name sortKey="Pike, Kerryn E" sort="Pike, Kerryn E" uniqKey="Pike K" first="Kerryn E." last="Pike">Kerryn E. Pike</name><name sortKey="Pike, Kerryn E" sort="Pike, Kerryn E" uniqKey="Pike K" first="Kerryn E." last="Pike">Kerryn E. Pike</name><name sortKey="Rowe, Christopher C" sort="Rowe, Christopher C" uniqKey="Rowe C" first="Christopher C." last="Rowe">Christopher C. Rowe</name><name sortKey="Rowe, Christopher C" sort="Rowe, Christopher C" uniqKey="Rowe C" first="Christopher C." last="Rowe">Christopher C. Rowe</name><name sortKey="Salvado, Olivier" sort="Salvado, Olivier" uniqKey="Salvado O" first="Olivier" last="Salvado">Olivier Salvado</name><name sortKey="Szoeke, Cassandra" sort="Szoeke, Cassandra" uniqKey="Szoeke C" first="Cassandra" last="Szoeke">Cassandra Szoeke</name><name sortKey="Villemagne, Victor L" sort="Villemagne, Victor L" uniqKey="Villemagne V" first="Victor L." last="Villemagne">Victor L. Villemagne</name><name sortKey="Villemagne, Victor L" sort="Villemagne, Victor L" uniqKey="Villemagne V" first="Victor L." last="Villemagne">Victor L. Villemagne</name><name sortKey="Villemagne, Victor L" sort="Villemagne, Victor L" uniqKey="Villemagne V" first="Victor L." last="Villemagne">Victor L. Villemagne</name></country><country name="France"><noRegion><name sortKey="Chetelat, Gael" sort="Chetelat, Gael" uniqKey="Chetelat G" first="Gaël" last="Chetelat">Gaël Chetelat</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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